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      Time and temperature are two variables
      that can affect the overall freedom from harmful levels of pathogens. The
      disease-causing microorganisms found in food need to be present in
      significant quantities in order to make someone ill after consuming it.
      Once pathogens have established themselves in a food source, they will
      either thrive or be destroyed, depending upon how time and temperature are
      manipulated. 
      
      Temperature 
      There are pathogens that can live at
      all temperature ranges. For most of those capable of causing food borne
      illness, however, the most friendly environment provides temperatures
      within a range of 4 to 60oC (40 to 140oF). They are
      usually destroyed at temperatures above 60oC. Storage at
      temperatures below 4oC will destroy some pathogens; the cycle
      of growth and reproduction will be slowed or interrupted in others. 
      
      Time 
      When conditions are favorable,
      pathogens can grow and reproduce at an astonishing rate. There are four
      distinct stages of bacterial growth. The first is the lag phase, during
      which newly introduced bacteria become adjusted to their environment.
      During the accelerated growth phase, the bacteria reproduce rapidly.
      Bacteria reproduce asexually; as each bacterium grows, it will split into
      two bacteria of equal size. Under ideal circumstances, each bacterium can
      reproduce every 20 minutes. One bacterium could produce 72 million
      bacteria in just 12 hours. 
      The growth phase leads to the
      stationary phase. This is a plateau, during which the rate of growth and
      reproduction is matched by the rate of elimination. At this point, there
      is no increase in the number of bacteria. Finally, there is the decline
      phase. Now, the essential elements for life are exhausted. The elimination
      rate exceeds the growth rate. 
      The time during which foods remain in
      the danger zone is one of the most critical to the prevention of
      contamination through food borne illness. 
      
      
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